Antibodiesinc/Anti-Tyrosine Hydroxylase (LNC1)/20 µL/77-700-020,Antibodiesinc,,Antibodiesinc,Antibodies Incorporated,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Antibodiesinc/Anti-Tyrosine Hydroxylase (LNC1)/20 µL/77-700-020

产品编号：77-700-020

市场价：¥2180.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>重组抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$109.00

品牌： Antibodiesinc

公司：Antibodies Incorporated

公司分类：

商品介绍

Brand:

AntibodiesIncorporated

AntibodyType:

Monoclonal

HostSpecies:

Mouse

AntibodyIsotype:

IgG1

SpeciesReactivity:

ChickenFrogHumanLizardMonkeyMouseRatVoleZebrafish

Applications:

ICCIHCIPWB

Immunogen:

TyrosineHydroxylasepurifiedfromPC12cells.

LNC1isanantibodywhichcanbeusedtodetectTyrosineHydroxylase(TH).THistherate-limitingenzymeinthesynthesisofthecatecholamineneurotransmittersdopamine,epinephrine,andnorepinephrineandisresponsIBLeforconvertingL-tyrosinetoL-dopa.SynthesisofcatecholaminesisregulatedbytheinteractionofTHwithits’cofactor,tetrahydrobiopterin(BH4)andthesubstratesL-tyrosineandmolecularoxygen.InhumansfourTHmRNAsplicevariants(hTH1-hTH4)havebeenisolatedwhilesubprimatespeciesrelyonasingleformofTH. ItisknownthatthehTH1-hTH4variantsareidenticalintheircatalyticdomainbutdifferintheirN-terminalregulatorydomains.Importantly,LNC1reactswiththecatalyticdomainofTHandthuswithallfourisoformsofhumanTH.TheroleofTHinthesynthesisofcatecholamineneurotransmitterssuggestsaconnectionbetweentheenzymeandanumberofneuropathogenicdiseasescharacterizedbyirregularcatecholaminelevels,suchasParkinson"sdisease,schizophrenia,anddystonia,aswellasavarietyofcardiovasculardiseases.

ProteinName(s):

Tyrosine3-monooxygenase

GeneName(s):

TH,TYH,EC1.14.16.2

品牌介绍

五十多年来，Antibodies Incorporated的员工一直致力于支持各地科学家的生命增长和突破性工作。我们以经过验证的神经科学抗体的广泛目录和受严格而悠久的质量管理体系支配的一系列服务来履行我们的使命-我们在美国加利福尼亚州的戴维斯进行所有工作。

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